Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats

Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats

Diabetes mellitus is a life-threatening metabolic disease. At the moment, there is no effective treatment available to combat it. In this study, we aimed to develop berberine-loaded bilosomes (BER-BLS) to boost the oral bioavailability and therapeutic efficacy of berberine, a natural antidiabetic me...

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Bibliographic Details
Main Authors: Mohammed H. Elkomy, Hussein M. Eid, Mohammed Elmowafy, Khaled Shalaby, Ameeduzzafar Zafar, Mohamed A. Abdelgawad, Mostafa E. Rateb, Mohammed R.A. Ali, Izzeddin Alsalahat, Heba A. Abou-Taleb
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Drug Delivery
Subjects:
Berberine
diabetes mellitus
bilosomes
bioavailability
pharmacokinetics
bile salts
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2022.2110997

Internet

https://www.tandfonline.com/doi/10.1080/10717544.2022.2110997

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