NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats

NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats

Abstract Background Neuroinflammation plays an important role in pathogenesis of germinal matrix hemorrhage (GMH). Neurotrophin-4 (NT-4) is a member of the neurotrophin family and interacts with the tropomyosin receptor kinase B (TrkB). NT-4 has been shown to confer neuroprotective effects following...

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Bibliographic Details
Main Authors: Tianyi Wang, Junyi Zhang, Peng Li, Yan Ding, Jiping Tang, Gang Chen, John H. Zhang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Neuroinflammation
Subjects:
Germinal matrix hemorrhage
Neurotrophin-4
TrkB
Neuroinflammation
hydrocephalus
Online Access:http://link.springer.com/article/10.1186/s12974-020-01835-z

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http://link.springer.com/article/10.1186/s12974-020-01835-z

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