Developmental exposures to common environmental contaminants, DEHP and lead, alter adult brain and blood hydroxymethylation in mice

Developmental exposures to common environmental contaminants, DEHP and lead, alter adult brain and blood hydroxymethylation in mice

Introduction: The developing epigenome changes rapidly, potentially making it more sensitive to toxicant exposures. DNA modifications, including methylation and hydroxymethylation, are important parts of the epigenome that may be affected by environmental exposures. However, most studies do not diff...

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Bibliographic Details
Main Authors: Rebekah L. Petroff, Raymond G. Cavalcante, Justin A. Colacino, Jaclyn M. Goodrich, Tamara R. Jones, Claudia Lalancette, Rachel K. Morgan, Kari Neier, Bambarendage P. U. Perera, Christine A. Rygiel, Laurie K. Svoboda, Kai Wang, Maureen A. Sartor, Dana C. Dolinoy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DNA methylation
DNA hydroxymethylation
lead (Pb)
phthalate
DEHP (di-(2-ethylhexyl) phthalate)
toxicoepigenetics
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1198148/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1198148/full

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