Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory Loss

Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory Loss

Gx-50 is a bioactive compound for the treatment of Alzheimer’s disease (AD) found in Sichuan pepper (Zanthoxylum bungeanum). In order to find a stronger anti-AD lead compound, 20 gx-50 (1–20) analogs have been designed and synthesized, and their molecular structures were determin...

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Bibliographic Details
Main Authors: Tian Chai, Xiao-Bo Zhao, Wei-Feng Wang, Yin Qiang, Xiao-Yun Zhang, Jun-Li Yang
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
Alzheimer’s disease
gx-50
DPPH assay
ThT assay
transgenic Drosophila model assay
Online Access:http://www.mdpi.com/1420-3049/23/10/2663

Internet

http://www.mdpi.com/1420-3049/23/10/2663

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