The Effect of Dietary Fat and Sucrose on Cognitive Functioning in Mice Lacking Insulin Signaling in Neuropeptide Y Neurons

The Effect of Dietary Fat and Sucrose on Cognitive Functioning in Mice Lacking Insulin Signaling in Neuropeptide Y Neurons

Obesogenic diets can produce hippocampal insulin resistance and impairments to hippocampal-dependent cognition. This study investigated the effect of disrupted insulin signaling in Neuropeptide Y (NPY) neurons on diet-induced deficits in hippocampal-dependent memory. Wild-type mice and mice that had...

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Bibliographic Details
Main Authors: Caitlin S. Mitchell, Elisabeth K. Goodman, Caitlin R. Tedesco, Kathy Nguyen, Lei Zhang, Herbert Herzog, Denovan P. Begg
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Physiology
Subjects:
hippocampus
spatial cognition
morris water maze
diet
NPY (neuropeptide Y)
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.841935/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.841935/full

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