Neutrophils From Children With Systemic Juvenile Idiopathic Arthritis Exhibit Persistent Proinflammatory Activation Despite Long-Standing Clinically Inactive Disease

Neutrophils From Children With Systemic Juvenile Idiopathic Arthritis Exhibit Persistent Proinflammatory Activation Despite Long-Standing Clinically Inactive Disease

Background: Systemic juvenile idiopathic arthritis (SJIA) is a chronic childhood arthropathy with features of autoinflammation. Early inflammatory SJIA is associated with expansion and activation of neutrophils with a sepsis-like phenotype, but neutrophil phenotypes present in longstanding and clini...

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Bibliographic Details
Main Authors: Rachel A. Brown, Maggie Henderlight, Thuy Do, Shima Yasin, Alexei A. Grom, Monica DeLay, Sherry Thornton, Grant S. Schulert
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
macrophage activation syndrome
S100
neutrophil subsets
gene expression
systemic JIA
autoinflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02995/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02995/full

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