3D-QSAR studies on CCR2B receptor antagonists: Insight into the structural requirements of (R)-3-aminopyrrolidine series of molecules based on CoMFA/CoMSIA models

3D-QSAR studies on CCR2B receptor antagonists: Insight into the structural requirements of (R)-3-aminopyrrolidine series of molecules based on CoMFA/CoMSIA models

Objective: Monocyte chemo attractant protein-1 (MCP-1) is a member of the CC-chemokine family and it selectively recruits leukocytes from the circulation to the site of inflammation through binding with the chemotactic cytokine receptor 2B (CCR2B). The recruitment and activation of selected populati...

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Bibliographic Details
Main Authors: Swetha Gade, Shaik Mahmood
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2012-01-01
Series:Journal of Pharmacy and Bioallied Sciences
Subjects:
(R)-3-aminopyrrolidine series
3D-QSAR
CCR2B
CoMFA
CoMSIA
Online Access:http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=2;spage=123;epage=133;aulast=Gade

Internet

http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=2;spage=123;epage=133;aulast=Gade

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