Molecular Mechanisms of HIV Protease Inhibitors Against HPV-Associated Cervical Cancer: Restoration of TP53 Tumour Suppressor Activities

Molecular Mechanisms of HIV Protease Inhibitors Against HPV-Associated Cervical Cancer: Restoration of TP53 Tumour Suppressor Activities

Cervical cancer is a Human Papilloma virus-related disease, which is on the rise in a number of countries, globally. Two essential oncogenes, E6 and E7, drive cell transformation and cancer development. These two oncoproteins target two of the most important tumour suppressors, p53 and pRB, for degr...

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Bibliographic Details
Main Authors: Lilian Makgoo, Salerwe Mosebi, Zukile Mbita
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
cervical cancer
human papilloma virus
p53
HIV protease inhibitors
E6
anti-HIV drugs
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.875208/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.875208/full

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