Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle

Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle

Abstract Background Acute-on-chronic liver failure (ACLF) is a refractory disease with high mortality, which is characterized by a pathophysiological process of inflammation-related dysfunction of energy metabolism. Jieduan-Niwan formula (JDNWF) is a eutherapeutic Chinese medicine formula for ACLF....

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Bibliographic Details
Main Authors: Jiajun Liang, Xiaoyi Wei, Weixin Hou, Hanjing Wang, Ruimin Ma, Yanbin Gao, Yuqiong Du, Qiuyun Zhang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Chinese Medicine
Subjects:
Acute-on-chronic liver failure (ACLF)
Jieduan-Niwan formula (JDNWF)
Metabolomics
TCA cycle
Energy metabolism
Mitochondrial quality control
Online Access:https://doi.org/10.1186/s13020-023-00858-x

Internet

https://doi.org/10.1186/s13020-023-00858-x

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