Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease

Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease

Non-cell autonomous mechanisms are involved in the pathogenesis of amyotrophic lateral sclerosis (ALS), an adult neurodegenerative disease characterized by selective motor neuron loss. While the emerging role of glial cells in ALS has been noted, the detailed cell-type-specific role of glial cells h...

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Bibliographic Details
Main Authors: Hirofumi Yamashita, Okiru Komine, Noriko Fujimori-Tonou, Koji Yamanaka
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
transcriptome
amyotrophic lateral sclerosis
microarray
neurodegeneration
astrocytes
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.1045647/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.1045647/full

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