Updated DPYD HapB3 haplotype structure and implications for pharmacogenomic testing

Updated DPYD HapB3 haplotype structure and implications for pharmacogenomic testing

Abstract The DPYD gene encodes dihydropyrimidine dehydrogenase, the rate‐limiting enzyme for the metabolism of fluoropyrimidines 5‐fluorouracil and capecitabine. Genetic variants in DPYD have been associated with altered enzyme activity, therefore accurate detection and interpretation is critical to...

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Bibliographic Details
Main Authors: Amy J. Turner, Cyrine E. Haidar, Wenjian Yang, Erin C. Boone, Steven M. Offer, Philip E. Empey, Andrew Haddad, Saba Tahir, Gunter Scharer, Ulrich Broeckel, Andrea Gaedigk
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13699

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https://doi.org/10.1111/cts.13699

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