YAP regulates cell size and growth dynamics via non-cell autonomous mediators

The Hippo pathway regulates organ size, regeneration, and cell growth by controlling the stability of the transcription factor, YAP (Yorkie in Drosophila). When there is tissue damage, YAP is activated allowing the restoration of homeostatic tissue size. The exact signals by which YAP is activated a...

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Bibliographic Details
Main Authors: Douaa Mugahid, Marian Kalocsay, Xili Liu, Jonathan Scott Gruver, Leonid Peshkin, Marc W Kirschner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/53404