Synthesis of N-phenethylquinazolin-4-amines via silylation-amination mediated by hexamethyldisilazane

Synthesis of N-phenethylquinazolin-4-amines via silylation-amination mediated by hexamethyldisilazane

N-phenethylquinazolin-4-amines have emerged as potential Mycobacterium tuberculosis cytochrome bd oxidase inhibitors and attractive scaffolds in tuberculosis drug discovery programs. The classical two-step strategy of chlorination-amination to synthesize such structures presents several operational...

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Bibliographic Details
Main Authors: Guilherme Arraché Gonçalves, Flávio Castro do Nascimento, Sidnei Moura e Silva, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Results in Chemistry
Subjects:
N-phenethylquinazolin-4-amines
Quinazolines
Hexamethyldisilazane
Silylation-amination
Solvent-free conditions
Cytochrome bd oxidase inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715622002582

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http://www.sciencedirect.com/science/article/pii/S2211715622002582

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