Chemokine Receptor CCR2b Enhanced Anti-tumor Function of Chimeric Antigen Receptor T Cells Targeting Mesothelin in a Non-small-cell Lung Carcinoma Model

Chemokine Receptor CCR2b Enhanced Anti-tumor Function of Chimeric Antigen Receptor T Cells Targeting Mesothelin in a Non-small-cell Lung Carcinoma Model

Chimeric antigen receptor (CAR) T cell therapy faces a number of challenges for the treatment of non-small-cell lung carcinoma (NSCLC), and efficient migration of circulating CAR T cells plays an important role in anti-tumor activity. In this study, a CAR specific for tumor antigen mesothelin (Msln-...

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Bibliographic Details
Main Authors: Yanan Wang, Jing Wang, Xinyi Yang, Jinlong Yang, Panpan Lu, Lin Zhao, Bokang Li, Hanyu Pan, Zhengtao Jiang, Xiaoting Shen, Zhiming Liang, Yue Liang, Huanzhang Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
CAR T cell therapy
CCR2b
MCP-1
migration
NSCLC
mesothelin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.628906/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.628906/full

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