Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation

Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation

Infant acute myeloid leukemia (AML) is a heterogeneous disease, genetically distinct from its adult counterpart. Chromosomal translocations involving the <i>KMT2A</i> gene (<i>MLL</i>) are especially common in affected infants of less than 1 year of age, and are associated wi...

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Bibliographic Details
Main Authors: Cristiana Barone, Roberto Orsenigo, Anna Cazzola, Elisabetta D’Errico, Arianna Patelli, Giulia Quattrini, Barbara Vergani, Silvia Bombelli, Sofia De Marco, Cristina D’Orlando, Cristina Bianchi, Biagio Eugenio Leone, Raffaella Meneveri, Andrea Biondi, Giovanni Cazzaniga, Terence Howard Rabbitts, Silvia Brunelli, Emanuele Azzoni
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
infant AML
Mll-Af9
hematopoiesis
hematopoietic stem cell
erythro-myeloid progenitors
cell of origin
Online Access:https://www.mdpi.com/2072-6694/15/14/3624

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https://www.mdpi.com/2072-6694/15/14/3624

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