Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines

Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines

Abstract Pain and inflammation contribute immeasurably to reduced quality of life, yet modern analgesic and anti-inflammatory therapeutics can cause dependence and side effects. Here, we screened 1444 plant extracts, prepared primarily from native species in California and the United States Virgin I...

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Bibliographic Details
Main Authors: Rían W. Manville, Ryan F. Yoshimura, Andriy V. Yeromin, Derk Hogenkamp, Jennifer van der Horst, Angel Zavala, Sonia Chinedu, Grey Arena, Emma Lasky, Mark Fisher, Christopher R. Tracy, Shivashankar Othy, Thomas A. Jepps, Michael D. Cahalan, Geoffrey W. Abbott
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06752-y

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https://doi.org/10.1038/s42003-024-06752-y

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