Identification of LncRNA Linc00513 Containing Lupus-Associated Genetic Variants as a Novel Regulator of Interferon Signaling Pathway

Identification of LncRNA Linc00513 Containing Lupus-Associated Genetic Variants as a Novel Regulator of Interferon Signaling Pathway

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by augmented type I interferon signaling. High-throughput technologies have identified plenty of SLE susceptibility single-nucleotide polymorphisms (SNPs) yet the exact roles of most of them are still unknown. Functiona...

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Bibliographic Details
Main Authors: Zhixin Xue, Chaojie Cui, Zhuojun Liao, Shiwei Xia, Pingjing Zhang, Jialin Qin, Qiang Guo, Sheng Chen, Qiong Fu, Zhihua Yin, Zhizhong Ye, Yuanjia Tang, Nan Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
single-nucleotide polymorphism
long non-coding RNA
systemic lupus erythematosus
interferon
CRISPR-dCas9
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02967/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02967/full

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