Lithium modulates miR‐1906 levels of mesenchymal stem cell‐derived extracellular vesicles contributing to poststroke neuroprotection by toll‐like receptor 4 regulation

Lithium modulates miR‐1906 levels of mesenchymal stem cell‐derived extracellular vesicles contributing to poststroke neuroprotection by toll‐like receptor 4 regulation

Abstract Lithium is neuroprotective in preclinical stroke models. In addition to that, poststroke neuroregeneration is stimulated upon transplantation of mesenchymal stem cells (MSCs). Preconditioning of MSCs with lithium further enhances the neuroregenerative potential of MSCs, which act by secreti...

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Bibliographic Details
Main Authors: Matteo Haupt, Xuan Zheng, Yaoyun Kuang, Simone Lieschke, Lisa Janssen, Bert Bosche, Fengyan Jin, Katharina Hein, Ertugrul Kilic, Vivek Venkataramani, Dirk M. Hermann, Mathias Bähr, Thorsten R. Doeppner
Format: Article
Language:English
Published: Oxford University Press 2021-03-01
Series:Stem Cells Translational Medicine
Subjects:
cerebral ischemia
extracellular vesicles
lithium
mesenchymal stem cells
miR‐1906
TLR4
Online Access:https://doi.org/10.1002/sctm.20-0086

Internet

https://doi.org/10.1002/sctm.20-0086

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