Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM-1 in rats

Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM-1 in rats

Abstract Background Trimethylamine oxide (TMAO) is a biomarker in cardiovascular and renal diseases. TMAO originates from the oxidation of trimethylamine (TMA), a product of gut microbiota and manufacturing industries-derived pollutant, by flavin monooxygenases (FMOs). The effect of chronic exposure...

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Bibliographic Details
Main Authors: Klaudia M. Maksymiuk, Mateusz Szudzik, Marta Gawryś-Kopczyńska, Maksymilian Onyszkiewicz, Emilia Samborowska, Izabella Mogilnicka, Marcin Ufnal
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Translational Medicine
Subjects:
Trimethylamine
Trimethylamine oxide
Chronic kidney disease
Hypertension
Proteinuria
Kidney damage
Online Access:https://doi.org/10.1186/s12967-022-03687-y

Internet

https://doi.org/10.1186/s12967-022-03687-y

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