Phenotypical Flexibility of the EGFRvIII-Positive Glioblastoma Cell Line and the Multidirectional Influence of TGFβ and EGF on These Cells—EGFRvIII Appears as a Weak Oncogene

Phenotypical Flexibility of the EGFRvIII-Positive Glioblastoma Cell Line and the Multidirectional Influence of TGFβ and EGF on These Cells—EGFRvIII Appears as a Weak Oncogene

Background: The biological role of EGFRvIII (epidermal growth factor receptor variant three) remains unclear. Methods: Three glioblastoma DK-MG sublines were tested with EGF (epidermal growth factor) and TGFβ (transforming growth factor β). Sublines were characterized by an increased percentage of E...

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Bibliographic Details
Main Authors: Aneta Włodarczyk, Cezary Tręda, Adrianna Rutkowska, Dagmara Grot, Weronika Dobrewa, Amelia Kierasińska, Marta Węgierska, Tomasz Wasiak, Tadeusz Strózik, Piotr Rieske, Ewelina Stoczyńska-Fidelus
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
EGFRvIII
EMT-like phenomenon
GB
TGFβ
senescence
Online Access:https://www.mdpi.com/1422-0067/23/20/12129

Internet

https://www.mdpi.com/1422-0067/23/20/12129

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