Sex-specific exposures and sex-combined outcomes in two-sample Mendelian randomization may mislead the causal inference

Abstract With great interest, we have read the recent article “Age at menarche, age at natural menopause, and risk of rheumatoid arthritis — a Mendelian randomization study” by Zhu et al. While we have a great appreciation for the work conducted by the authors, there are some methodological issues t...

Full description

Bibliographic Details
Main Authors: Zhenqian Wang, Jiawen Lu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Arthritis Research & Therapy
Subjects:
Online Access:https://doi.org/10.1186/s13075-022-02922-7