A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis

The kinase RAF1 usually exerts pro-tumorigenic functions promoting proliferation in RAS-driven cancers. Here, the authors using a mouse model of HCC and clinical data describe an unexpected oncosuppressor role of RAF1 in hepatocarcinoma development linked to a gp130-dependent Stat3 activation and YA...

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Bibliographic Details
Main Authors: Ines Jeric, Gabriele Maurer, Anna Lina Cavallo, Josipa Raguz, Enrico Desideri, Bartosz Tarkowski, Matthias Parrini, Irmgard Fischer, Kurt Zatloukal, Manuela Baccarini
Format: Article
Language:English
Published: Nature Portfolio 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13781

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https://doi.org/10.1038/ncomms13781

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