Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice

Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice

The bacterium <i>Clostridium botulinum</i> is the causative agent of botulism&#8212;a severe intoxication caused by botulinum neurotoxin (BoNT) and characterized by damage to the nervous system. In an effort to develop novel <i>C. botulinum</i> immunotherapeutics, camelid...

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Bibliographic Details
Main Authors: Svetlana A. Godakova, Anatoly N. Noskov, Irina D. Vinogradova, Galina A. Ugriumova, Andrey I. Solovyev, Ilias B. Esmagambetov, Amir I. Tukhvatulin, Denis Y. Logunov, Boris S. Naroditsky, Dmitry V. Shcheblyakov, Aleksandr L. Gintsburg
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Toxins
Subjects:
camelid single-domain antibodies
VHH
<i>Clostridium botulinum</i>
toxin neutralization
phage display
dimers
Fc fragments
Online Access:https://www.mdpi.com/2072-6651/11/8/464

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https://www.mdpi.com/2072-6651/11/8/464

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