Skipping Exon-v6 from CD44v6-Containing Isoforms Influences Chemotherapy Response and Self-Renewal Capacity of Gastric Cancer Cells

Skipping Exon-v6 from CD44v6-Containing Isoforms Influences Chemotherapy Response and Self-Renewal Capacity of Gastric Cancer Cells

De novo expressed CD44 isoforms containing exon-v6 are frequently associated with gastric cancer (GC) aggressiveness, and may predict chemotherapy response in vitro. Whether exon-v6 itself is responsible for conferring these properties to CD44v6-containing isoforms remains to be elucidated. CRISPR/C...

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Bibliographic Details
Main Authors: Silvana Lobo, Carla Pereira, Carla Oliveira, Gabriela M. Almeida
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
CRISPR/Cas9
chemoresistance
exon skipping
morpholinos
cell survival
stomach neoplasms
Online Access:https://www.mdpi.com/2072-6694/12/9/2378

Internet

https://www.mdpi.com/2072-6694/12/9/2378

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