Multilevel Regulation of NF‐κB Signaling by NSD2 Suppresses Kras‐Driven Pancreatic Tumorigenesis

Multilevel Regulation of NF‐κB Signaling by NSD2 Suppresses Kras‐Driven Pancreatic Tumorigenesis

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer with a dismal overall prognosis. NSD2 is an H3K36‐specific di‐methyltransferase that has been reported to play a crucial role in promoting tumorigenesis. Here, the study demonstrates that NSD2 acts as a putative tumo...

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Bibliographic Details
Main Authors: Wenxin Feng, Ningning Niu, Ping Lu, Zhuo Chen, Hanyu Rao, Wei Zhang, Chunxiao Ma, Changwei Liu, Yue Xu, Wei‐Qiang Gao, Jing Xue, Li Li
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:Advanced Science
Subjects:
H3K36me2
Kras
multilevel regulation
NF‐κB signaling
NSD2
p65
Online Access:https://doi.org/10.1002/advs.202309387

Internet

https://doi.org/10.1002/advs.202309387

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