Amide C–N bonds activation by A new variant of bifunctional N-heterocyclic carbene

Amide C–N bonds activation by A new variant of bifunctional N-heterocyclic carbene

Abstract We report an organocatalyst that combines a triazolium N-heterocyclic carbene (NHC) with a squaramide as a hydrogen-bonding donor (HBD), which can effectively catalyze the atroposelective ring-opening of biaryl lactams via a unique amide C–N bond cleavage mode. The free carbene species atta...

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Bibliographic Details
Main Authors: Yuxing Cai, Yuxin Zhao, Kai Tang, Hong Zhang, Xueling Mo, Jiean Chen, Yong Huang
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44756-8

Internet

https://doi.org/10.1038/s41467-024-44756-8

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