Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer’s pathology stages

Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer’s pathology stages

Abstract The locus coeruleus (LC) has been identified as a site that develops phosphorylated tau pathology earlier than cerebral cortex. We present data using high-resolution postmortem MRI and validated tau histopathology in controls and the earliest Braak and Braak (BB) stages (BBI-BBII) in LC. Th...

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Bibliographic Details
Main Authors: Alexander T. Hary, Smriti Chadha, Nathaniel Mercaldo, Erin-Marie C. Smith, André J. W. van der Kouwe, Bruce Fischl, Christopher Mount, Liana Kozanno, Matthew P. Frosch, Jean C. Augustinack
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Acta Neuropathologica Communications
Subjects:
Brainstem
Upper pons
Locus coeruleus
Dorsal raphe nucleus
Early tau pathology
Spatial temporal heatmap
Online Access:https://doi.org/10.1186/s40478-025-01957-6

Internet

https://doi.org/10.1186/s40478-025-01957-6

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