phydms: software for phylogenetic analyses informed by deep mutational scanning

It has recently become possible to experimentally measure the effects of all amino-acid point mutations to proteins using deep mutational scanning. These experimental measurements can inform site-specific phylogenetic substitution models of gene evolution in nature. Here we describe software that ef...

Full description

Bibliographic Details
Main Authors: Sarah K. Hilton, Michael B. Doud, Jesse D. Bloom
Format: Article
Language:English
Published: PeerJ Inc. 2017-07-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/3657.pdf