The chromatin remodeling protein CHD-1 and the EFL-1/DPL-1 transcription factor cooperatively down regulate CDK-2 to control SAS-6 levels and centriole number.

The chromatin remodeling protein CHD-1 and the EFL-1/DPL-1 transcription factor cooperatively down regulate CDK-2 to control SAS-6 levels and centriole number.

Centrioles are submicron-scale, barrel-shaped organelles typically found in pairs, and play important roles in ciliogenesis and bipolar spindle assembly. In general, successful execution of centriole-dependent processes is highly reliant on the ability of the cell to stringently control centriole nu...

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Bibliographic Details
Main Authors: Jyoti Iyer, Lindsey K Gentry, Mary Bergwell, Amy Smith, Sarah Guagliardo, Peter A Kropp, Prabhu Sankaralingam, Yan Liu, Eric Spooner, Bruce Bowerman, Kevin F O'Connell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009799

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https://doi.org/10.1371/journal.pgen.1009799

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