Circulating Tumor Cells Develop Resistance to TRAIL-Induced Apoptosis Through Autophagic Removal of Death Receptor 5: Evidence from an In Vitro Model

Circulating Tumor Cells Develop Resistance to TRAIL-Induced Apoptosis Through Autophagic Removal of Death Receptor 5: Evidence from an In Vitro Model

Circulating tumor cells (CTCs) in the peripheral blood are the precursors to distant metastasis but the underlying mechanisms are poorly understood. This study aims at understanding the molecular features within CTCs, in relation to their metastatic potential. Using in vitro CTC models, in which bre...

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Bibliographic Details
Main Authors: Julianne D. Twomey, Baolin Zhang
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
circulating tumor cells
CTCs
breast cancer
metastasis
death receptor
TRAIL
apoptosis
in vitro model
Online Access:http://www.mdpi.com/2072-6694/11/1/94

Internet

http://www.mdpi.com/2072-6694/11/1/94

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