Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels

Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels

Abstract Background Although the advent of combination anti-retroviral therapy (cART) has transformed HIV into a manageable chronic disease, an estimated 30–50% of people living with HIV (PLWH) exhibit cognitive and motor deficits collectively known as HIV-associated neurocognitive disorders (HAND)....

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Bibliographic Details
Main Authors: Marina McDew-White, Eunhee Lee, Lakmini S. Premadasa, Xavier Alvarez, Chioma M. Okeoma, Mahesh Mohan
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Neuroinflammation
Subjects:
THC
SIV
Rhesus macaque
Neuroinflammation
Type-I interferon
Microbiota–gut–brain axis
Online Access:https://doi.org/10.1186/s12974-023-02729-6

Internet

https://doi.org/10.1186/s12974-023-02729-6

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