Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis

Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis

Abstract Background Dual-specificity phosphatases (DUSPs) can dephosphorylate both tyrosine and serine/threonine residues of their substrates and regulate T cell-mediated immunity and autoimmunity. The aim of this study was to investigate the potential roles of DUSPs in ankylosing spondylitis (AS)....

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Bibliographic Details
Main Authors: Ming-Han Chen, Huai-Chia Chuang, Yi-Chen Yeh, Chung-Tei Chou, Tse-Hua Tan
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Medicine
Subjects:
DUSP22
Ankylosing spondylitis
Tumor necrosis factor-α
Interferon-γ
Interleukin-17A
Online Access:https://doi.org/10.1186/s12916-023-02745-6

Internet

https://doi.org/10.1186/s12916-023-02745-6

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