Differential Sensitivity of the Protein Translation Initiation Machinery and mTOR Signaling to <i>MECP2</i> Gain- and Loss-of-Function Involves MeCP2 Isoform-Specific Homeostasis in the Brain

Differential Sensitivity of the Protein Translation Initiation Machinery and mTOR Signaling to <i>MECP2</i> Gain- and Loss-of-Function Involves MeCP2 Isoform-Specific Homeostasis in the Brain

Eukaryotic gene expression is controlled at multiple levels, including gene transcription and protein translation initiation. One molecule with key roles in both regulatory mechanisms is methyl CpG binding protein 2 (MeCP2). <i>MECP2</i> gain- and loss-of-function mutations lead to Rett...

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Bibliographic Details
Main Authors: Marjorie Buist, Nada El Tobgy, Danilo Shevkoplyas, Matthew Genung, Annan Ali Sher, Shervin Pejhan, Mojgan Rastegar
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
epigenetics
MeCP2 isoforms
MeCP2E1
gene transcription
BDNF
brain development
Online Access:https://www.mdpi.com/2073-4409/11/9/1442

Internet

https://www.mdpi.com/2073-4409/11/9/1442

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