Do distribution volumes and clearances relate to tissue volumes and blood flows? A computer simulation

<p>Abstract</p> <p>Background</p> <p>Kinetics of inhaled agents are often described by physiological models. However, many pharmacokinetic concepts, such as context-sensitive half-times, have been developed for drugs described by classical compartmental models. We deriv...

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Bibliographic Details
Main Authors: Lemmens Hendrikus JM, Hendrickx Jan FA, Shafer Steven L
Format: Article
Language:English
Published: BMC 2006-06-01
Series:BMC Anesthesiology
Online Access:http://www.biomedcentral.com/1471-2253/6/7