HER2 and HLA-A*02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity

HER2 and HLA-A*02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity

Background One of the major challenges in chimeric antigen receptor (CAR)-T cell therapy for solid tumors is the potential for on-target off-tumor toxicity due to the expression of CAR tumor antigens in essential tissues and organs. Here, we describe a dual CAR NOT gate incorporating an inhibitory C...

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Bibliographic Details
Main Authors: Sarit Tabak, David Bassan, Leehee Weinberger, Jason Yi, Tanya Kim, Caitlin Schnair, Kristina Vucci, Neta Chaim, Nir Bujanover, Yael Lopesco, Orit Foord, Adi Sharbi-Yunger, Michael R Weist, Gregor B Adams, Limor Levy-Knafo, Richard L Kendall, Frank J Calzone
Format: Article
Language:English
Published: BMJ Publishing Group 2023-12-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/12/e007426.full

Internet

https://jitc.bmj.com/content/11/12/e007426.full

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