A drug screening to identify novel combinatorial strategies for boosting cancer immunotherapy efficacy

A drug screening to identify novel combinatorial strategies for boosting cancer immunotherapy efficacy

Abstract Background Chimeric antigen receptor (CAR) T cells and immune checkpoint blockades (ICBs) have made remarkable breakthroughs in cancer treatment, but the efficacy is still limited for solid tumors due to tumor antigen heterogeneity and the tumor immune microenvironment. The restrained treat...

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Bibliographic Details
Main Authors: Zongliang Zhang, Guoqing Wang, Kunhong Zhong, Yongdong Chen, Nian Yang, Qizhong Lu, Boyang Yuan, Zeng Wang, Hexian Li, Liping Guo, Ruyuan Zhang, Zhiguo Wu, Meijun Zheng, Shasha Zhao, Xin Tang, Bin Shao, Aiping Tong
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Translational Medicine
Subjects:
Small molecular screening
JK184
B7-H3 CAR T
ICBs
Solid tumor
Online Access:https://doi.org/10.1186/s12967-023-03875-4

Internet

https://doi.org/10.1186/s12967-023-03875-4

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