Elevated extracellular matrix protein 1 in circulating extracellular vesicles supports breast cancer progression under obesity conditions

Elevated extracellular matrix protein 1 in circulating extracellular vesicles supports breast cancer progression under obesity conditions

Abstract The cargo content in small extracellular vesicles (sEVs) changes under pathological conditions. Our data shows that in obesity, extracellular matrix protein 1 (ECM1) protein levels are significantly increased in circulating sEVs, which is dependent on integrin-β2. Knockdown of integrin-β2 d...

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Bibliographic Details
Main Authors: Keyang Xu, Ai Fu, Zhaoyi Li, Liangbin Miao, Zhonghan Lou, Keying Jiang, Condon Lau, Tao Su, Tiejun Tong, Jianfeng Bao, Aiping Lyu, Hiu Yee Kwan
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45995-5

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https://doi.org/10.1038/s41467-024-45995-5

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