Advances in Detecting Low Prevalence Somatic TERT Promoter Mutations in Papillary Thyroid Carcinoma

Advances in Detecting Low Prevalence Somatic TERT Promoter Mutations in Papillary Thyroid Carcinoma

BackgroundTwo recurrent TERT (telomerase reverse transcriptase) promoter mutations, C228T and C250T, have been reported in thyroid carcinomas and were correlated with high-risk clinicopathological features and a worse prognosis. Although far more frequent in the poorly differentiated and undifferent...

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Bibliographic Details
Main Authors: Vitor Rodrigues da Costa, Larissa Valdemarin Bim, Luiza Dornelles Penteado Pacheco e Silva, Gabriel Avelar Colloza-Gama, André Uchimura Bastos, Rosana Delcelo, Gisele Oler, Janete Maria Cerutti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Endocrinology
Subjects:
Papillary thyroid carcinoma
TERT (telomerase reverse transcriptase)
C250T
C228T
droplet digital PCR
TaqMan allele discrimination assay
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.643151/full

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https://www.frontiersin.org/articles/10.3389/fendo.2021.643151/full

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