Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress

Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress

Tightly regulated and robust mitochondrial activities are critical for normal hearing. Previously, we demonstrated that Fus1/Tusc2 KO mice with mitochondrial dysfunction exhibit premature hearing loss. Molecular analysis of the cochlea revealed hyperactivation of the mTOR pathway, oxidative stress,...

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Bibliographic Details
Main Authors: Winston J. T. Tan, Joseph Santos-Sacchi, Jane Tonello, Anil Shanker, Alla V. Ivanova
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Antioxidants
Subjects:
age-related hearing loss
cochlea
Fus1/Tusc2
mitochondria
mitochondrial dysfunction
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/12/6/1225

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https://www.mdpi.com/2076-3921/12/6/1225

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