Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Objective: Glucose-dependent insulinotropic polypeptide (GIP) is one of the two major incretin factors that regulate metabolic homeostasis. Genetic ablation of its receptor (GIPR) in mice confers protection against diet-induced obesity (DIO), while GIPR neutralizing antibodies produce additive weigh...

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Bibliographic Details
Main Authors: Bin Yang, Vasily M. Gelfanov, Kimberley El, Alex Chen, Rebecca Rohlfs, Barent DuBois, Ann Maria Kruse Hansen, Diego Perez-Tilve, Patrick J. Knerr, David D'Alessio, Jonathan E. Campbell, Jonathan D. Douros, Brian Finan
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Metabolism
Subjects:
Peptide antagonist
GIP/GIPR
GLP-1/GLP-1R
Obesity
Diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822002071

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http://www.sciencedirect.com/science/article/pii/S2212877822002071

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