Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch

Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch

Gastrin-releasing peptide receptors (GRPR) are involved in pruriceptive behaviours. Here the authors show that neuronal pentraxin 2 upregulated in primary sensory neurons in chronic itch models is required for facilitating excitatory synaptic inputs onto GRPR expressing spinal neurons.

Bibliographic Details
Main Authors: Kensho Kanehisa, Keisuke Koga, Sho Maejima, Yuto Shiraishi, Konatsu Asai, Miho Shiratori-Hayashi, Mei-Fang Xiao, Hirotaka Sakamoto, Paul F. Worley, Makoto Tsuda
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30089-x

Internet

https://doi.org/10.1038/s41467-022-30089-x

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