Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma

Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma

Ewing sarcoma (EWS) is an aggressive pediatric malignancy of the bone and soft tissues in need of novel therapeutic options. To identify potential therapeutic targets, we focused on essential biological pathways that are upregulated by EWS-FLI1, the primary oncogenic driver of EWS, including mitotic...

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Bibliographic Details
Main Authors: Soumya M. Turaga, Vikalp Vishwakarma, Stacey L. Hembruff, Benjamin K. Gibbs, Priya Sabu, Rajni V. Puri, Harsh B. Pathak, Glenson Samuel, Andrew K. Godwin
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
Ewing sarcoma
drug synergy
kinesin family member 11
Aurora kinase A
SB-743921
VIC-1911
Online Access:https://www.mdpi.com/2072-6694/15/20/4911

Internet

https://www.mdpi.com/2072-6694/15/20/4911

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