Akt signaling is activated by TGFβ2 and impacts tenogenic induction of mesenchymal stem cells

Akt signaling is activated by TGFβ2 and impacts tenogenic induction of mesenchymal stem cells

Abstract Background Tissue engineered and regenerative approaches for treating tendon injuries are challenged by the limited information on the cellular signaling pathways driving tenogenic differentiation of stem cells. Members of the transforming growth factor (TGF) β family, particularly TGFβ2, p...

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Bibliographic Details
Main Authors: Sophia K. Theodossiou, Jett B. Murray, LeeAnn A. Hold, Jeff M. Courtright, Anne M. Carper, Nathan R. Schiele
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Stem Cell Research & Therapy
Subjects:
Tendon
Tenogenesis
Mesenchymal stem cells
Tissue engineering
Akt
Smad3
Online Access:https://doi.org/10.1186/s13287-021-02167-2

Internet

https://doi.org/10.1186/s13287-021-02167-2

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