Determination of spinal tracer dispersion after intrathecal injection in a deformable CNS model

Determination of spinal tracer dispersion after intrathecal injection in a deformable CNS model

Background: Traditionally, there is a widely held belief that drug dispersion after intrathecal (IT) delivery is confined locally near the injection site. We posit that high-volume infusions can overcome this perceived limitation of IT administration.Methods: To test our hypothesis, subject-specific...

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Bibliographic Details
Main Authors: Ayankola O. Ayansiji, Daniel S. Gehrke, Bastien Baralle, Ariel Nozain, Meenesh R. Singh, Andreas A. Linninger
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Physiology
Subjects:
geometry-induced mixing
intrathecal drug delivery
method of moments
oscillatory CSF flow
in vitro deformable spine model
drug infusion parameters
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1244016/full

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https://www.frontiersin.org/articles/10.3389/fphys.2023.1244016/full

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