HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction

HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction

Aims: Naturally secreted extracellular vesicles (EVs) play important roles in stem-mediated cardioprotection. This study aimed to investigate the cardioprotective function and underlying mechanisms of EVs derived from HIF-1α engineered mesenchymal stem cells (MSCs) in a rat model of AMI. Methods and...

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Bibliographic Details
Main Authors: Qingjie Wang, Le Zhang, Zhiqin Sun, Boyu Chi, Ailin Zou, Lipeng Mao, Xu Xiong, JianGuang Jiang, Ling Sun, Wenwu Zhu, Yuan Ji
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Materials Today Bio
Subjects:
Hypoxia inducible factor-1α
Extracellular Vesicles
Mesenchymal stem cells
myocardial infarction
Online Access:http://www.sciencedirect.com/science/article/pii/S259000642100079X

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http://www.sciencedirect.com/science/article/pii/S259000642100079X

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