Bile acid-mediated signaling in cholestatic liver diseases
Abstract Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are associated with bile stasis and gradually progress to fibrosis, cirrhosis, and liver failure, which requires liver transplantation. Although ursodeoxycholic acid is ef...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-023-01035-1 |
| _version_ | 1797836214563241984 |
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| author | Jing Zeng Jiangao Fan Huiping Zhou |
| author_facet | Jing Zeng Jiangao Fan Huiping Zhou |
| author_sort | Jing Zeng |
| collection | DOAJ |
| description | Abstract Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are associated with bile stasis and gradually progress to fibrosis, cirrhosis, and liver failure, which requires liver transplantation. Although ursodeoxycholic acid is effective in slowing the disease progression of PBC, it has limited efficacy in PSC patients. It is challenging to develop effective therapeutic agents due to the limited understanding of disease pathogenesis. During the last decade, numerous studies have demonstrated that disruption of bile acid (BA) metabolism and intrahepatic circulation promotes the progression of cholestatic liver diseases. BAs not only play an essential role in nutrition absorption as detergents but also play an important role in regulating hepatic metabolism and modulating immune responses as key signaling molecules. Several excellent papers have recently reviewed the role of BAs in metabolic liver diseases. This review focuses on BA-mediated signaling in cholestatic liver disease. |
| first_indexed | 2024-04-09T15:06:17Z |
| format | Article |
| id | doaj.art-5beb17d93ca44d25bbe941d45db9483d |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-04-09T15:06:17Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-5beb17d93ca44d25bbe941d45db9483d2023-04-30T11:29:44ZengBMCCell & Bioscience2045-37012023-04-0113111510.1186/s13578-023-01035-1Bile acid-mediated signaling in cholestatic liver diseasesJing Zeng0Jiangao Fan1Huiping Zhou2Department of Microbiology and Immunology, Medical College of Virginia and Richmond VA Medical Center, Central Virginia Veterans Healthcare System, Virginia Commonwealth UniversityDepartment of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Microbiology and Immunology, Medical College of Virginia and Richmond VA Medical Center, Central Virginia Veterans Healthcare System, Virginia Commonwealth UniversityAbstract Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are associated with bile stasis and gradually progress to fibrosis, cirrhosis, and liver failure, which requires liver transplantation. Although ursodeoxycholic acid is effective in slowing the disease progression of PBC, it has limited efficacy in PSC patients. It is challenging to develop effective therapeutic agents due to the limited understanding of disease pathogenesis. During the last decade, numerous studies have demonstrated that disruption of bile acid (BA) metabolism and intrahepatic circulation promotes the progression of cholestatic liver diseases. BAs not only play an essential role in nutrition absorption as detergents but also play an important role in regulating hepatic metabolism and modulating immune responses as key signaling molecules. Several excellent papers have recently reviewed the role of BAs in metabolic liver diseases. This review focuses on BA-mediated signaling in cholestatic liver disease.https://doi.org/10.1186/s13578-023-01035-1CholestasisBile acidsBile acid receptorsFXRTGR5S1PR2 |
| spellingShingle | Jing Zeng Jiangao Fan Huiping Zhou Bile acid-mediated signaling in cholestatic liver diseases Cell & Bioscience Cholestasis Bile acids Bile acid receptors FXR TGR5 S1PR2 |
| title | Bile acid-mediated signaling in cholestatic liver diseases |
| title_full | Bile acid-mediated signaling in cholestatic liver diseases |
| title_fullStr | Bile acid-mediated signaling in cholestatic liver diseases |
| title_full_unstemmed | Bile acid-mediated signaling in cholestatic liver diseases |
| title_short | Bile acid-mediated signaling in cholestatic liver diseases |
| title_sort | bile acid mediated signaling in cholestatic liver diseases |
| topic | Cholestasis Bile acids Bile acid receptors FXR TGR5 S1PR2 |
| url | https://doi.org/10.1186/s13578-023-01035-1 |
| work_keys_str_mv | AT jingzeng bileacidmediatedsignalingincholestaticliverdiseases AT jiangaofan bileacidmediatedsignalingincholestaticliverdiseases AT huipingzhou bileacidmediatedsignalingincholestaticliverdiseases |