Apoptotic extracellular vesicles derived from hypoxia-preconditioned mesenchymal stem cells within a modified gelatine hydrogel promote osteochondral regeneration by enhancing stem cell activity and regulating immunity

Apoptotic extracellular vesicles derived from hypoxia-preconditioned mesenchymal stem cells within a modified gelatine hydrogel promote osteochondral regeneration by enhancing stem cell activity and regulating immunity

Abstract Due to its unique structure, articular cartilage has limited abilities to undergo self-repair after injury. Additionally, the repair of articular cartilage after injury has always been a difficult problem in the field of sports medicine. Previous studies have shown that the therapeutic use...

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Bibliographic Details
Main Authors: Zhengang Ding, Zineng Yan, Xun Yuan, Guangzhao Tian, Jiang Wu, Liwei Fu, Han Yin, Songlin He, Chao Ning, Yazhe Zheng, Zhichao Zhang, Xiang Sui, Libo Hao, Yuting Niu, Shuyun Liu, Weimin Guo, Quanyi Guo
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Nanobiotechnology
Subjects:
Cartilage injury
Stem cell-derived apoptotic extracellular vesicles
Hypoxia
Modified gelatine matrix
3D printing
Online Access:https://doi.org/10.1186/s12951-024-02333-7

Internet

https://doi.org/10.1186/s12951-024-02333-7

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