Peptide Location Fingerprinting Reveals Tissue Region-Specific Differences in Protein Structures in an Ageing Human Organ

Peptide Location Fingerprinting Reveals Tissue Region-Specific Differences in Protein Structures in an Ageing Human Organ

In ageing tissues, long-lived extracellular matrix (ECM) proteins are susceptible to the accumulation of structural damage due to diverse mechanisms including glycation, oxidation and protease cleavage. Peptide location fingerprinting (PLF) is a new mass spectrometry (MS) analysis technique capable...

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Bibliographic Details
Main Authors: Alexander Eckersley, Matiss Ozols, Peikai Chen, Vivian Tam, Judith A. Hoyland, Andrew Trafford, Danny Chan, Michael J. Sherratt
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
proteomics
peptide location fingerprinting
extracellular matrix
ageing
intervertebral disc
spine
Online Access:https://www.mdpi.com/1422-0067/22/19/10408

Internet

https://www.mdpi.com/1422-0067/22/19/10408

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