A Multi‐Functional Nanoadjuvant Coupling Manganese with Toll‐Like 9 Agonist Stimulates Potent Innate and Adaptive Anti‐Tumor Immunity

A Multi‐Functional Nanoadjuvant Coupling Manganese with Toll‐Like 9 Agonist Stimulates Potent Innate and Adaptive Anti‐Tumor Immunity

Abstract The effectiveness of Toll‐like 9 agonists (CpG) as an adjuvant for tumor immunotherapy is restricted due to their insufficient ability to activate anti‐tumor immunity. To address that, the common nutrient metal ions are explored (Mn2+, Cu2+, Ca2+, Mg2+, Zn2+, Fe3+, and Al3+), identifying Mn...

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Bibliographic Details
Main Authors: Zhongjie Liu, Shu Li, Yang Xiao, Xiaoyang Liu, Bin Zhang, Qin Zeng, Qiang Ao, Xingdong Zhang
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
manganese
nanoadjuvant
TLR9 agonist
tumor immunotherapy
vaccine
Online Access:https://doi.org/10.1002/advs.202402678

Internet

https://doi.org/10.1002/advs.202402678

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