Isothiourea‐Catalyzed Enantioselective Functionalisation of Glycine Schiff Base Aryl Esters via 1,6‐ and 1,4‐Additions

Isothiourea‐Catalyzed Enantioselective Functionalisation of Glycine Schiff Base Aryl Esters via 1,6‐ and 1,4‐Additions

Abstract The enantioselective α‐functionalisation of glycine Schiff base aryl esters through isothiourea catalysis is successfully demonstrated for 1,6‐additions to para‐quinone methides (21 examples, up to 95 : 5 dr and 96 : 4 er) and 1,4‐ additions to methylene substituted dicarbonyl or disulfonyl...

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Bibliographic Details
Main Authors: Lotte Stockhammer, Rebecca Craik, Prof. Dr. Uwe Monkowius, Dr. David B. Cordes, Prof. Dr. Andrew D. Smith, Prof. Dr. Mario Waser
Format: Article
Language:English
Published: Wiley-VCH 2023-07-01
Series:ChemistryEurope
Subjects:
1,6- and 1,4-addition
α-amino acid derivatives
enantioselective
glycine Schiff base
isothiourea
Online Access:https://doi.org/10.1002/ceur.202300015

Internet

https://doi.org/10.1002/ceur.202300015

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